Behavioral Neuroscience, lecture on neuromuscular function
LORDOSIS
XIV. Neuromuscular Function
A. ACh secreted from motor neuron projecting from the ventral horn
1. Lumbosacral spinal cord
a. to lateral longissimus and transversospinalis muscles
2. may be inhibited by spinal GABA interneurons
a. acting on GABAA receptors
B. ACh binds to Nicotinic receptors at a neuromuscular synapse
1. stumulates action potential (= end-plate potential or EPP)
2. Opening transmitter-gated Na+, Ca++ and K+ channel
(a large diameter channel)
a. EPP passes along sarcolemma and into transverse tubules
i. opens voltage gated Ca++ channels in
sarcoplasmic reticulum
(1) binds to troponin
(a) conformational change in tropomyosin
uncovers binding site for myosin on actin
(i) myosin binds to actin
(ii) conformational change
(muscle contracts)
(iii) ATP allows unbinding of actin
ii. Ca++ATPase returns Ca++ to cisternae
of sarcoplasmic reticulum
C. Useful Movement: bilateral dorsiflexion of entire vertebral
column by lateral longissimus and transversospinalis muscles
1. Contractile force summates for each muscle cell
a. requires repeated EPP's (before fiber relaxes)
i. \requires Ca++ restoration to cisternae
ii. \contractile force depends on initial length
2. the Nervous System Grades the force of muscle contraction
a. single motor axon innervates a single muscle fiber (cell)
b. one motor neuron (many axons) innervates a number of muscle
fibers = Motor Unit
i. smallest functional unit
(1) magnitude of contractile function depends on
innervation ratio (fibers/neuron)
c. graded force is dependent upon motor unit recruitment
d. motor units are recruited in a fixed order
i. weakest to strongest
(1) allows fine motor actions
ii. not necessary for Lordosis
(1) deep back muscles contract with maximum
force to support male
(2) termination of descending axons across
a wide range of lumbosacral spinal cord levels
produce a ballistic muscular ressponse
e. ñ firing rate ñ force
i. more effective summation (see C 1)